Mer receptor tyrosine kinase is a promising novel cancer therapeutic target in many human cancers, because abnormal activation of Mer has been implicated in survival signaling and chemoresistance.3D-QSAR analyses based on alignment independent descriptors were performed on a series of 81 Mer specific tyrosine kinase inhibitors.The fractional factor
Background.Neurofibromatosis type 1 is a genetic disorder caused by loss-of-function mutations in neutral checkered phone case a tumor suppressor gene (NF1) which codifies the protein neurofibromin.The frequent genetic alterations that modify neurofibromin function are deletions and insertions.Duplications are rare and phenotype in patients bearing
The Ca(2+)-sensing receptor (CaSR) regulates Ca(2+) homeostasis in the body by monitoring extracellular levels of Ca(2+) ([Ca(2+)]o) and amino acids.Mutations at the hinge region of the N-terminal Venus flytrap domain (VFTD) produce either receptor inactivation (L173P, P221Q) or nautica voyage hajuvesi activation (L173F, P221L) related to hypercalc
Maria P Romero,1,2 Hilde H Buzza,1 Mirian diablo 2 amn D Stringasci,1 Bianca M Estevão,1 Cecilia CC Silva,3 Marcelo A Pereira-da-Silva,1 Natalia M Inada,1 Vanderlei S Bagnato1 1São Carlos Institute of Physics, IFSC/USP, São Carlos, São Paulo, Brazil; 2Departamento de Materiales, Facultad de Ingeniería Mecán
BackgroundA role of Chlamydia trachomatis in HPV-induced cervical carcinogenesis has been reported for cervical cancer but studies on cervical adenocarcinoma are limited.MethodsA total of 1,553 cervical smears taken up to 26 years before diagnosis in a large population-based nested case-control study of cervical adenocarcinoma (AC, 132 cases with m